Abstract We introduce DESMAN for De novo Extraction of Strains from Metagenomes. Large multi-sample metagenomes are being generated but strain variation results in fragmentary co-assemblies. Current algorithms can bin contigs into metagenome-assembled genomes but are unable to resolve strain-level variation. https://www.roneverhart.com/HP-Pavilion-15-eg1053cl-15-6-FHD-Touch-Intel-Core-i5-1235U-3-30-GHz-Intel-Iris-Xe-Graphics-12-GB-DDR4-RAM-512-GB-SSD-/